In this course I explain when it's appropriate to use jQuery and when it may not be. If you do need jQuery then I'll discuss making a custom build that includes only the parts you need. The rest of the course is focused on converting common jQuery snippets to either use native browser APIs or utilize a popular micro-library.
Don't get me wrong, I love jQuery. It has proven its value and it very much has its place. However, you may have seen some buzz around the web about the concept of not using it at all.
In addition, it is just a good idea to know how to get around the native DOM without the necessity of a helper library such as jQuery, Dojo, MooTools, Prototype, etc...